Trichloromethane or methyl trichloride
are other names for chloroform. Dr Samuel Guthrie, an American scientist, first
created chloroform in 1831. He had carried out the rudimentary synthesis, which
consisted of combining whiskey with chlorinated lime. He was, in fact,
attempting a cost-effective pesticide synthesis. Dutch Liquid was the name of
the insecticide (the chemical formula is C2H4Cl2 ). It is a natural organic
chemical molecule that was once used as an ideal anaesthetic. It's a colourless
compound with a sweet odour and a dense liquid consistency. Because of the
chlorination process in drinking water, wastewater, and swimming pools, this
chemical may be released into the air. This is a chemical that can be used as a
lachrymator in industry. It has a non-flammable property, making it safer to
handle than ethanol.
Chloroform has a tight margin of safety and has
been phased out in favour of more effective inhalation anaesthetics.
Furthermore, it is thought to be toxic to the liver and kidneys, and it has the
potential to cause liver cancer. Chloroform was originally widely used as a
solvent, however it has since been phased out due to safety and environmental
concerns. Despite this, chloroform remains a significant industrial chemical.
The chlorination of methane produces
chloroform. Chloroform is primarily used in the production of
chlorodifluoromethane (HCFC-22). Because HCFC-22 contributes to ozone
depletion, its production in the United States will be phased out by 2020.
Chloroform production is predicted to drop dramatically once HCFC-22
manufacture is phased out. Chloroform is created when chlorine reacts with
organic molecules in water, and it can therefore be found in chlorinated
drinking water. The US Environmental Protection Agency has set an
80-parts-per-billion (ppb) limit for chloroform contamination; a typical
municipal water supply contains about 50 ppb.
Chloroform is a great solvent for
alkaloids in their natural state. Chloroform, which contains deuterium (CDCl3),
is often employed as a solvent in NMR spectroscopy in laboratories. Chloroform
is also used extensively in the manufacture of the Freon refrigerant R-22. It
is used in laboratories to preserve organic tissues, such as anatomical
specimens, and to keep them from decaying. It's also utilised in photographs,
waxes, fats, oils, resins, greases, adhesives, and dry cleaning as an
industrial solvent.
Chloroform is used to extract morphine
from scopolamine and poppies from Datura plants for commercial purposes.
Chloroform is used in molecular biology for a variety of purposes, including
DNA extraction from cells, extraction of mineral oil from polymerase chain
reaction samples, DNA recovery from polyacrylamide gels, handling phenol, lambda
cDNA storage, lambda plaque storage, and plasmid DNA extraction.
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Drinking chloroform-laced water or
eating chloroform-laced food for an extended length of time might harm the
liver and kidneys. Touching liquid chloroform can cause skin irritation and
blisters. Chronic exposure to chloroform, according to medical science, might
cause dizziness, fatigue, drowsiness, memory loss, increased dreams, anorexia,
and palpitations. Higher quantities of serum prealbumin and transferrin levels
could indicate mild liver injury.
Physical Characteristics of Chloroform
is a clear liquid with an ether-like odour and a slightly sweet taste. Although
it is a naturally occurring substance, the majority of chloroform in the
environment is man-made. It is water soluble. Today, the United States produces
nearly all of the chloroform used in the production of other chemicals.
However, it also sells or trades some of its products with other countries.
India imports chloroform as well.
Chemical Properties - The reaction of
chloroform with acetone is extremely explosive in alkaline media or in the
presence of a solid base. Dinitrogen tetraoxide and chloroform combinations are
also explosive. Polyhalogenated organic compounds, which are a very important
class of chemicals, are made possible by the high reactivity rate of halogens.
Chloroform is a member of this group of chemicals. Despite the fact that such
substances have been discovered to have negative impacts on the environment as
well as the human body. Despite this, because of their great utility and wide
variety of applications, businesses continue to use these compounds.
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